High throughput screening for discovery of materials that control stem cell fate
File(s)
Author(s)
Type
Journal Article
Abstract
nsights into the complex stem cell niche have identified the cell–material interface to be a potent reg-
ulator of stem cell fate via material properties such as chemistry, topography and stiffness. In light of this,
materials scientists have the opportunity to develop bioactive materials for stem cell culture that elicit
specific cellular responses. To accelerate materials discovery, high throughput screening platforms have
been designed which can rapidly evaluate combinatorial material libraries in two and three-dimensional
environments. In this review, we present screening platforms for the discovery of material properties that
influence stem cell behavior.
ulator of stem cell fate via material properties such as chemistry, topography and stiffness. In light of this,
materials scientists have the opportunity to develop bioactive materials for stem cell culture that elicit
specific cellular responses. To accelerate materials discovery, high throughput screening platforms have
been designed which can rapidly evaluate combinatorial material libraries in two and three-dimensional
environments. In this review, we present screening platforms for the discovery of material properties that
influence stem cell behavior.
Date Issued
2016-02-22
Date Acceptance
2016-02-07
Citation
CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE, 2016, 20 (4), pp.202-211
ISSN
1359-0286
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Start Page
202
End Page
211
Journal / Book Title
CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE
Volume
20
Issue
4
Copyright Statement
© 2016 The Authors. Published by Elsevier Ltd. ThisisanopenaccessarticleundertheCCBYlicense(
http://
creativecommons.org/licenses/by/4.0/
).
http://
creativecommons.org/licenses/by/4.0/
).
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000382408500004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Technology
Physical Sciences
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Materials Science
Physics
Stem cells
Differentiation
Biomaterials
High throughput screening
3D
TERM SELF-RENEWAL
EXTRACELLULAR-MATRIX
CARDIOMYOCYTE DIFFERENTIATION
COMBINATORIAL APPROACH
PROGENITOR CELLS
HYDROGELS
CULTURE
POLYMER
BIOMATERIALS
SURFACES
0912 Materials Engineering
Materials
Publication Status
Published