The impact of the timely birth-dose vaccine on the global elimination of hepatitis B
File(s)
Published version
Author(s)
de Villiers, Margaret
Nayagam, Amanda Shevanthi
Hallett, Timothy
Type
Journal Article
Abstract
In 2016 the World Health Organization set the goal of eliminating hepatitis B globally by 2030. Horizontal transmission has been greatly reduced in most countries by scaling up coverage of the infant HBV vaccine series, and vertical transmission is therefore becoming increasingly dominant. Here we show that scaling up timely hepatitis B birth dose vaccination to 90% of new-borns in 110 low- and middle-income countries by 2030 could prevent 710,000 (580,000 to 890,000) deaths in the 2020 to 2030 birth cohorts compared to status quo, with the greatest benefits in Africa. Maintaining this could lead to elimination by 2030 in the Americas, but not before 2059 in Africa. Drops in coverage due to disruptions in 2020 may lead to 15,000 additional deaths, mostly in South-East Asia and the Western Pacific. Delays in planned scale-up could lead to an additional 580,000 deaths globally in the 2020 to 2030 birth cohorts.
Date Issued
2021-10-28
Date Acceptance
2021-09-27
Citation
Nature Communications, 2021, 12 (6223), pp.1-10
ISSN
2041-1723
Publisher
Nature Research
Start Page
1
End Page
10
Journal / Book Title
Nature Communications
Volume
12
Issue
6223
Copyright Statement
© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
License URL
Sponsor
Medical Research Council (MRC)
Identifier
https://www.nature.com/articles/s41467-021-26475-6
Grant Number
MR/R015600/1
Subjects
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
TO-CHILD TRANSMISSION
VIRUS INFECTION
NATURAL-HISTORY
SURFACE-ANTIGEN
CHRONIC CARRIERS
NEWBORN-INFANTS
IMMUNIZATION
PREVENTION
COVID-19
MOTHERS
Publication Status
Published
Date Publish Online
2021-10-28