Microcirculation of blood and interstitial fluid in a poroelastic model of the
liver
liver
File(s)
Author(s)
Argungu, M
Tweedy, JH
Type
Conference Paper
Abstract
Cirrhosis is a life-threatening condition that represents a leading cause of death
in the western world. In this condition the structure of the liver tissue is altered by
the development of fibrosis, which means it becomes stiffer and its permeability to
blood and interstitial flow within the tissue that are vital to its function are reduced.
We develop a new mathematical model based on those by Bonfiglio et al (2010) and
Siggers et al (2014), which we use to investigate the changes in liver volume, blood
flow and lymphatic uptake, which measures interstitial flow, that occur as the tissue
becomes progressively stiffer. Our results suggest that the typical changes that develop
during cirrhosis have a significant effect on the permeability properties, highlighting
the seriousness of this condition.
in the western world. In this condition the structure of the liver tissue is altered by
the development of fibrosis, which means it becomes stiffer and its permeability to
blood and interstitial flow within the tissue that are vital to its function are reduced.
We develop a new mathematical model based on those by Bonfiglio et al (2010) and
Siggers et al (2014), which we use to investigate the changes in liver volume, blood
flow and lymphatic uptake, which measures interstitial flow, that occur as the tissue
becomes progressively stiffer. Our results suggest that the typical changes that develop
during cirrhosis have a significant effect on the permeability properties, highlighting
the seriousness of this condition.
Date Issued
2017-07-06
Date Acceptance
2017-02-17
Citation
Conference Proceedings of 6th Biot Conference on Poromechanics, 2017, pp.1126-1134
Publisher
ASCE
Start Page
1126
End Page
1134
Journal / Book Title
Conference Proceedings of 6th Biot Conference on Poromechanics
Copyright Statement
© 2017 American Society of Civil Engineers. This material may be downloaded for personal use only. Any other use requires prior permission of the American Society of Civil Engineers. This material may be found at https://ascelibrary.org/doi/book/10.1061/9780784480779
Source
6th Bio Conference on Poromechanics 2017
Publication Status
Published
Start Date
2017-07-09
Finish Date
2017-07-13
Coverage Spatial
Paris, France
Date Publish Online
2017-07-06