Formation of folates by microorganisms: towards the biotechnological production of this vitamin
File(s)
Published version
Author(s)
Revuelta, José Luis
Serrano-Amatriain, Cristina
Ledesma-Amaro, Rodrigo
Jiménez, Alberto
Type
Journal Article
Abstract
Folates (vitamin B9) are essential micronutrients which function as cofactors in one-carbon transfer reactions involved in the synthesis of nucleotides and amino acids. Folate deficiency is associated with important diseases such as cancer, anemia, cardiovascular diseases, or neural tube defects. Epidemiological data show that folate deficiency is still highly prevalent in many populations. Hence, food fortification with synthetic folic acid (i.e., folic acid supplementation) has become mandatory in many developed countries. However, folate biofortification of staple crops and dairy products as well as folate bioproduction using metabolically engineered microorganisms are promising alternatives to folic acid supplementation. Here, we review the current strategies aimed at overproducing folates in microorganisms, in view to implement an economic feasible process for the biotechnological production of the vitamin.
Date Issued
2018-10-01
Date Acceptance
2018-07-24
Citation
Applied Microbiology and Biotechnology, 2018, 102 (20), pp.8613-8620
ISSN
0175-7598
Publisher
Springer Verlag
Start Page
8613
End Page
8620
Journal / Book Title
Applied Microbiology and Biotechnology
Volume
102
Issue
20
Copyright Statement
© The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/30073396
PII: 10.1007/s00253-018-9266-0
Subjects
Ashbya gossypii
Folate biofortification
Metabolic engineering
Microbial production
Vitamin B9
Publication Status
Published
Coverage Spatial
Germany
Date Publish Online
2018-08-02