Development of hepatic pathology in GBV‐B‐infected red‐bellied tamarins ( Saguinus labiatus)
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
GB virus B (GBV‐B) is a New World monkey‐associated flavivirus used to model acute hepatitis C virus (HCV) infection. Critical for evaluation of anti‐viral or vaccine approaches is an understanding of the effect of HCV on the liver at different stages of infection. In the absence of longitudinal human tissue samples at defined time points, we have characterised changes in tamarins. As early as two weeks post infection histological changes were noticeable, and these were established in all animals by six weeks. Despite high levels of liver‐associated viral RNA there was reversal of hepatic damage on clearance of peripheral virus though fibrosis was demonstrated in four tamarins. Notably, viral RNA burden in the liver dropped to near undetectable or background levels in all animals which underwent a second viral challenge, highlighting the efficacy of the immune response in removing foci of replication in the liver. These data add to the knowledge of GBV‐B infection in New World primates which can offer attractive systems for the testing of prophylactic and therapeutic treatments and the evaluation of their utility in preventing or reversing liver pathology.
Date Issued
2020-12-01
Date Acceptance
2020-03-01
Citation
Journal of Medical Virology, 2020, 92 (12), pp.3584-3595
ISSN
0146-6615
Publisher
Wiley
Start Page
3584
End Page
3595
Journal / Book Title
Journal of Medical Virology
Volume
92
Issue
12
Copyright Statement
© 2020 Crown copyright. Journal of Medical Virology published by Wiley Periodicals, Inc. This article is published with the permission of the Controller of HMSO and the Queen's Printer for Scotland.
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Identifier
https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25769
Subjects
Science & Technology
Life Sciences & Biomedicine
Virology
animal models of infection
hepatitis virus
local infection
replication
spread
C VIRUS
COMMON MARMOSETS
LIVER-DAMAGE
T-CELLS
MODEL
PERSISTENCE
IMMUNITY
AGENT
animal models of infection
hepatitis virus
local infection
replication
spread
Virology
0605 Microbiology
1108 Medical Microbiology
Publication Status
Published
Article Number
jmv.25769
Date Publish Online
2020-03-17