Posttraumatic osteoarthritis: what have we learned to advance osteoarthritis?
File(s)COR-S-20-00070 (1)_Updated submitted.pdf (1.41 MB)
Accepted version
Author(s)
Watt, Fiona E
Type
Journal Article
Abstract
PURPOSE OF REVIEW: Current thinking in the study of posttraumatic osteoarthritis (PTOA) is overviewed: the osteoarthritis which follows acute joint injury. The review particularly highlights important publications in the last 18 months, also reflecting on key older literature, in terms of what have we have we learned and have yet to learn from PTOA, which can advance the osteoarthritis field as a whole. RECENT FINDINGS: PTOA is a mechanically driven disease, giving insight into mechanical drivers for osteoarthritis. A mechanosensitive molecular tissue injury response (which includes activation of pain, degradative and also repair pathways) is triggered by acute joint injury and seen in osteoarthritis. Imaging features of PTOA are highly similar to osteoarthritis, arguing against it being a different phenotype. The inflammatory pathways activated by injury contribute to early joint symptoms. However, later structural changes appear to be dissociated from traditional measures of synovial inflammation. SUMMARY: PTOA remains an important niche in which to understand processes underlying osteoarthritis and seek interventional targets. Whether PTOA has true molecular or clinical differences to osteoarthritis as a whole remains to be understood. This knowledge is important for a field where animal modelling of the disease relies heavily on the link between injury and osteoarthritis.
Date Issued
2021-01
Date Acceptance
2021-01-01
Citation
Current Opinion in Rheumatology, 2021, 33 (1), pp.74-83
ISSN
1040-8711
Publisher
Lippincott, Williams & Wilkins
Start Page
74
End Page
83
Journal / Book Title
Current Opinion in Rheumatology
Volume
33
Issue
1
Copyright Statement
© 2020 Wolters Kluwer Health, Inc. All rights reserved.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/33186246
PII: 00002281-202101000-00011
Subjects
Animals
Biomechanical Phenomena
Humans
Inflammation
Joints
Magnetic Resonance Imaging
Models, Animal
Osteoarthritis
Phenotype
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2021-01-01