Where are the affective psychoses?: A systematic review and meta-analysis of the proportion of people with primary affective disorders presenting to early intervention services
File(s)
Accepted version
Supporting information
Author(s)
Catalan, Ana
Swidzinski, Samuel
Young, Allan
Jauhar, Sameer
Type
Journal Article
Abstract
Background: People with affective psychotic disorders often face diagnostic delays and presentations are under-recognised at first contact with Early Intervention Services (EIS). Despite their clinical significance, most research and service models for first-episode psychosis (FEP) have focused on non-affective psychoses. Aim: Clarifying the relative prevalence of affective psychoses in EIS.
Method: A systematic review and random-effects meta-analysis of observational studies reporting proportion of affective psychotic disorders among individuals presenting to EIS with FEP (PROSPERO: CRD42021257473) was conducted. Eligible studies included treated FEP populations diagnosed using DSM /ICD criteria. Searches were conducted in Web of Science, MEDLINE, and PsycINFO (inception to July 2025). The primary outcome was pooled proportion of affective psychotic disorders. Heterogeneity was assessed using Q statistics and I². Meta-regressions examined potential moderators, including urbanicity, national income level, and geographical region.
Results: Eighty-three studies (n = 30,946; mean age 24.95 years; 34.78% female) were included. Random-effects pooled proportion was 18.0% (95% CI 15.4–20.6; 95% prediction interval 3.6–39.4%; I² = 95.6%). Schizoaffective disorder represented 7.4% (k = 49; 95% CI: 5.8–9.2). Schizophrenia was the most frequent diagnosis, with a pooled proportion of 45.5% (k = 79; 95% CI: 40.3–50.7). Meta-regression analyses identified that affective psychoses were less common in Asia and more common in North America compared to Europe. Higher urbanicity and national income were also associated with increased prevalence.
Conclusions: Affective psychotic disorders constitute a meaningful subgroup within EIS. This suggests better screening, targeted treatments and adaptive service models of care.
Method: A systematic review and random-effects meta-analysis of observational studies reporting proportion of affective psychotic disorders among individuals presenting to EIS with FEP (PROSPERO: CRD42021257473) was conducted. Eligible studies included treated FEP populations diagnosed using DSM /ICD criteria. Searches were conducted in Web of Science, MEDLINE, and PsycINFO (inception to July 2025). The primary outcome was pooled proportion of affective psychotic disorders. Heterogeneity was assessed using Q statistics and I². Meta-regressions examined potential moderators, including urbanicity, national income level, and geographical region.
Results: Eighty-three studies (n = 30,946; mean age 24.95 years; 34.78% female) were included. Random-effects pooled proportion was 18.0% (95% CI 15.4–20.6; 95% prediction interval 3.6–39.4%; I² = 95.6%). Schizoaffective disorder represented 7.4% (k = 49; 95% CI: 5.8–9.2). Schizophrenia was the most frequent diagnosis, with a pooled proportion of 45.5% (k = 79; 95% CI: 40.3–50.7). Meta-regression analyses identified that affective psychoses were less common in Asia and more common in North America compared to Europe. Higher urbanicity and national income were also associated with increased prevalence.
Conclusions: Affective psychotic disorders constitute a meaningful subgroup within EIS. This suggests better screening, targeted treatments and adaptive service models of care.
Date Acceptance
2026-02-10
Citation
The British journal of psychiatry. Supplement
ISSN
0960-5371
Publisher
Cambridge University Press
Journal / Book Title
The British journal of psychiatry. Supplement
Copyright Statement
Copyright This paper is embargoed until publication. Once published the author’s accepted manuscript will be made available under a CC-BY License in accordance with Imperial’s Research Publications Open Access policy (www.imperial.ac.uk/oa-policy).
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Publication Status
Accepted