MetaboListem and TABoLiSTM: two deep learning algorithms for metabolite named entity recognition
File(s)metabolites-12-00276.pdf (4.08 MB)
Published version
OA Location
Author(s)
Yeung, Cheng
Beck, Tim
Posma, Joram Matthias
Type
Journal Article
Abstract
Reviewing the metabolomics literature is becoming increasingly difficult because of the rapid expansion of relevant journal literature. Text-mining technologies are therefore needed to facilitate more efficient literature reviews. Here we contribute a standardised corpus of full-text publications from metabolomics studies and describe the development of two metabolite named entity recognition (NER) methods. These methods are based on Bidirectional Long Short-Term Memory (BiLSTM) networks and each incorporate different transfer learning techniques (for tokenisation and word embedding). Our first model (MetaboListem) follows prior methodology using GloVe word embeddings. Our second model exploits BERT and BioBERT for embedding and is named TABoLiSTM (Transformer-Affixed BiLSTM). The methods are trained on a novel corpus annotated using rule-based methods, and evaluated on manually annotated metabolomics articles. MetaboListem (F1 score 0.890, precision 0.892, recall 0.888) and TABoLiSTM (BioBERT version: F1 score 0.909, precision 0.926, recall 0.893) have achieved state-of-the-art performance on metabolite NER. A training corpus with full-text sentences from $>$1,000 full-text Open Access metabolomics publications with 105,335 annotated metabolites was created, as well as a manually annotated test corpus (19,138 annotations). This work demonstrates that deep learning algorithms are capable of identifying metabolite names accurately and efficiently in text. The proposed corpus and NER algorithms can be used for metabolomics text-mining tasks such as information retrieval, document classification and literature-based discovery. They are available from https://github.com/omicsNLP/MetaboliteNER.
Editor(s)
Salek, Reza
van der Hooft, Justin
Hassoun, Soha
Rogers, Simon
Date Issued
2022-03-22
Date Acceptance
2022-03-17
Citation
Metabolites, 2022, 12 (4), pp.1-23
ISSN
2218-1989
Publisher
MDPI AG
Start Page
1
End Page
23
Journal / Book Title
Metabolites
Volume
12
Issue
4
Copyright Statement
© 2022 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
License URL
Sponsor
Medical Research Council (MRC)
Medical Research Council
Identifier
https://www.biorxiv.org/content/10.1101/2022.02.22.481457v1
Grant Number
MR/S004033/1
MR/S004033/1
Subjects
deep learning
named entity recognition
natural language processing
Publication Status
Published
Article Number
276
Date Publish Online
2022-03-22