The behavior of a simple and innovative multi-layer sandwich panels having a polypropylene honeycomb core has been investigated carefully, theoretically and experimentally. A four-point bending test was performed to detect the mechanical characteristics of the multi-layer core. The experimental results emphasize a better rigidity of the multi-layer structure compared to the weakness displayed by the single-layer configuration. In fact, a small increase in the final weight of the component leads to a significant increase of the mechanical properties. In the second part of this study, analytical and numerical homogenization approaches were developed to compute the effective properties of the single polypropylene honeycomb core. The numerical model complies with the experimental protocol, and the simulation conducted is aiming to reproduce a typical four-point bending test on a polypropylene honeycomb multi-layer sandwich panel. Both numerical and experimental results are presented in details and a good correlation between them is highlighted.