[Emerging roles of neutrophils in the prognosis of colorectal cancer]
File(s)
Published version
Author(s)
Mantilla, Alejandra
Ramírez-Ramírez, María de Lourdes
Berlanga-Taylor, Antonio Jorge
Vadillo, Eduardo
Type
Journal Article
Abstract
Colorectal cancer (CRC) is one of the most frequent and lethal cancers in Mexico and the world. It is noteworthy that globally, the incidence of CRC is increasing at a rate of 2% per year in patients younger than 50 years of age. Its early detection, primarily based on colonoscopy screening starting at 45 years of age, is an essential weapon to reduce its mortality. When CRC is detected, the treatment is surgical; however, the pathology reports and biomedical research on the tumor microenvironment may offer new parameters that could serve as prognostic biomarkers. In this respect, the presence or absence of neutrophils associated with neoplastic tissues may indicate their prognostic relevance for the disease. Although this field is still controversial, our recently published evidence suggests that the presence of neutrophils with an anti-tumoral phenotype, particularly at the invasive margin of the colon tumors, could indicate a favorable prognosis. This emerging information suggests that the characterization of immune cells, particularly neutrophils, could contribute to assessing the evolution of CRC and identifying patients at increased risk of recurrences. In this article, we discuss relevant points that should be addressed when interpreting neutrophil-related data in the context of CRC.
Date Issued
2024-11-04
Date Acceptance
2024-07-22
Citation
Revista medica del Instituto Mexicano del Seguro Social, 2024, 62 (6), pp.1-7
ISSN
0443-5117
Publisher
Officina de Bibliotecas y Divulgacion de la Jefatura de los Servicios de Ensenanza e Investigacion
Start Page
1
End Page
7
Journal / Book Title
Revista medica del Instituto Mexicano del Seguro Social
Volume
62
Issue
6
Copyright Statement
© 2024 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/39570812
PII: e6169
Subjects
Biomarkers, Tumor
Colorectal Neoplasms
Humans
Neutrophils
Prognosis
Tumor Microenvironment
Biomarkers, Tumor
Colonic Neoplasms
Neutrophils
Phenotype
Tumor Microenvironment
Publication Status
Published
Coverage Spatial
Mexico
Article Number
e6169
Date Publish Online
2024-11-04