Chlamydia trachomatis-induced cell-mediated and humoral immune response in women with unexplained infertility
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
PROBLEM: What is the role of past Chlamydia trachomatis infection in unexplained infertility? METHOD OF STUDY: This is a prospective study of the impact of past C. trachomatis infection on pregnancy rates in 96 women with unexplained infertility. Both humoral and cell-mediated immune responses (CMI) against C. trachomatis were studied. Serum C. trachomatis IgG antibodies were analyzed using major outer membrane protein (MOMP) peptide-based ELISA. CMI was studied by lymphocyte proliferation (LP) assay in vitro. Data on given fertility treatment, time to pregnancy, and pregnancy outcome were collected. RESULTS: Altogether, 11.5% of the 96 women had C. trachomatis IgG antibodies. LP response to C. trachomatis was positive in 62.9% women. The overall pregnancy rate or live birth rate did not differ by the presence of antichlamydial antibodies or CMI against C. trachomatis. Time to spontaneous pregnancy was longer among C. trachomatis sero-positive women than among sero-negative women (2.9 years vs 2.0 years, P = .03). CONCLUSION: Past chlamydial infection does not play a major role in unexplained infertility. Women with unexplained infertility and positive immune response to C. trachomatis do not have reduced pregnancy rates, but time to spontaneous pregnancy is longer among C. trachomatis IgG sero-positive women than among sero-negative women.
Date Issued
2018-07-01
Date Acceptance
2018-04-03
Citation
American Journal of Reproductive Immunology, 2018, 80 (1), pp.1-6
ISSN
1046-7408
Publisher
Wiley
Start Page
1
End Page
6
Journal / Book Title
American Journal of Reproductive Immunology
Volume
80
Issue
1
Copyright Statement
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Rantsi, T, Joki‐Korpela, P, Öhman, H, et al. Chlamydia trachomatis‐induced cell‐mediated and humoral immune response in women with unexplained infertility. Am J Reprod Immunol. 2018; 80:e12865. , which has been published in final form at https://doi.org/10.1111/aji.12865. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/29693287
Subjects
Chlamydia trachomatis
cell mediated immune response
humoral immune response
live birth rate
unexplained infertility
Publication Status
Published
Coverage Spatial
Denmark
Date Publish Online
2018-04-25