HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome.
File(s)
Published version
Author(s)
Lai, RP
Meintjes, G
Wilkinson, RJ
Type
Journal Article
Abstract
Patients co-infected with HIV-1 and tuberculosis (TB) are at risk of developing TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) following commencement of antiretroviral therapy (ART). TB-IRIS is characterized by transient but severe localized or systemic inflammatory reactions against Mycobacterium tuberculosis antigens. Here, we review the risk factors and clinical management of TB-IRIS, as well as the roles played by different aspects of the immune response in contributing to TB-IRIS pathogenesis.
Date Issued
2015-09-30
Date Acceptance
2015-09-21
Citation
Seminars in Immunopathology, 2015, 38 (2), pp.185-198
ISSN
1863-2300
Publisher
Springer Verlag (Germany)
Start Page
185
End Page
198
Journal / Book Title
Seminars in Immunopathology
Volume
38
Issue
2
Copyright Statement
© The Author(s) 2015. This article is published with open access at Springerlink.com (http://creativecommons.org/licenses/by/4.0/)
License URL
Sponsor
Wellcome Trust
Identifier
PII: 10.1007/s00281-015-0532-2
Grant Number
104803/Z/14/ZR
Subjects
Drug therapy-complications
HIV-1 infection
Immune reconstitution inflammatory syndrome
Tuberculosis
Publication Status
Published