Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort
Author(s)
Type
Journal Article
Abstract
Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive.
Data suggest risk associations vary by tumour characteristics.
Methods: We conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)
to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n ¼ 565 cases). Multivariable conditional logistic
regression models were used to estimate associations.
Results: We observed no association between IGF-I and EOC overall or by tumour characteristics.
Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum
IGF-I concentrations may not influence EOC risk.
Data suggest risk associations vary by tumour characteristics.
Methods: We conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)
to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n ¼ 565 cases). Multivariable conditional logistic
regression models were used to estimate associations.
Results: We observed no association between IGF-I and EOC overall or by tumour characteristics.
Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum
IGF-I concentrations may not influence EOC risk.
Date Issued
2015-11-04
Date Acceptance
2014-10-08
Citation
British Journal of Cancer, 2015, 112 (1), pp.162-166
ISSN
1532-1827
Publisher
Cancer Research UK
Start Page
162
End Page
166
Journal / Book Title
British Journal of Cancer
Volume
112
Issue
1
Copyright Statement
© 2015 Cancer Research UK. From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License.
To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
Subjects
Science & Technology
Life Sciences & Biomedicine
Oncology
IGF-I
ovarian cancer
histological subtypes
carcinogenesis
type I/type II
dualistic pathway
SERUM IGF-I
FOLLICULAR-FLUID
STRATEGIES
Publication Status
Published