A systematic review and meta-analysis of animal studies investigating the relationship between serum antibody, T lymphocytes, and respiratory syncytial virus disease
Author(s)
Type
Journal Article
Abstract
BACKGROUND: Respiratory syncytial virus (RSV) infections occur in human populations around the globe, causing disease of variable severity, disproportionately affecting infants and older adults (>65 years of age). Immune responses can be protective but also contribute to disease. Experimental studies in animals enable detailed investigation of immune responses, provide insights into clinical questions, and accelerate the development of passive and active vaccination. We aimed to review the role of antibody and T-cell responses in relation to RSV disease severity in animals. METHODS: Systematic review and meta-analysis of animal studies examining the association between T-cell responses/phenotype or antibody titers and severity of RSV disease. The PubMed, Zoological Record, and Embase databases were screened from January 1980 to May 2018 to identify animal studies of RSV infection that assessed serum antibody titer or T lymphocytes with disease severity as an outcome. Sixty-three studies were included in the final review. RESULTS: RSV-specific antibody appears to protect from disease in mice, but such an effect was less evident in bovine RSV. Strong T-cell, Th1, Th2, Th17, CD4/CD8 responses, and weak Treg responses accompany severe disease in mice. CONCLUSIONS: Murine studies suggest that measures of T-lymphocyte activity (particularly CD4 and CD8 T cells) may be predictive biomarkers of severity. Further inquiry is merited to validate these results and assess relevance as biomarkers for human disease.
Date Issued
2022-08-01
Date Acceptance
2021-07-15
Citation
Journal of Infectious Diseases, 2022, 226 (Supplement_1), pp.S117-S129
ISSN
0022-1899
Publisher
Oxford University Press
Start Page
S117
End Page
S129
Journal / Book Title
Journal of Infectious Diseases
Volume
226
Issue
Supplement_1
Copyright Statement
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. This is a pre-copy-editing, author-produced version of an article accepted for publication in Journal of Infectious Diseases following peer review. The definitive publisher-authenticated version is available online at: https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiab370/6370415
Sponsor
National Institute for Health Research
National Institute for Health Research
Imperial College Healthcare NHS Trust- BRC Funding
Medical Research Council (MRC)
Imperial College Healthcare NHS Trust- BRC Funding
National Institute for Health Research
Medical Research Council (MRC)
Commission of the European Communities
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/34522970
PII: 6370415
Grant Number
NF-SI-0513-10150
HPRU-2012-10064
RDA02
MR/T50256X/1
RDA02
NIHR201385
MR/T031565/1
116019
Subjects
RSV
RSV antibody
T lymphocyte
animal model
disease severity
meta-analysis
systematic review
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2021-09-15