Putative involvement of cytokine modulation in the development of peri-operative neurocognitive disorders
File(s)
Author(s)
Pereira, Christopher
Dani, melanie
Taylor-Robinson, simon
Fertleman, michael
Type
Journal Article
Abstract
Following surgery, local cytokine-driven inflammation occurs, as part of the normal healing process. Cytokines in the
central nervous system such as IL-6 and IL-8 may also be elevated. These cytokine changes likely contribute to neuroinflammation,
but the complex mechanisms through which this occurs are incompletely understood. It may be that perioperative changes in pro- and
anti-inflammatory cytokines have a role in the development of perioperative neurocognitive disorders (PND), such as post-operative
delirium (POD). This review considers the current evidence regarding perioperative cytokine changes in the blood and cerebrospinal
fluid (CSF), as well as considering the potential for cytokine-altering therapies to prevent and treat PND.
central nervous system such as IL-6 and IL-8 may also be elevated. These cytokine changes likely contribute to neuroinflammation,
but the complex mechanisms through which this occurs are incompletely understood. It may be that perioperative changes in pro- and
anti-inflammatory cytokines have a role in the development of perioperative neurocognitive disorders (PND), such as post-operative
delirium (POD). This review considers the current evidence regarding perioperative cytokine changes in the blood and cerebrospinal
fluid (CSF), as well as considering the potential for cytokine-altering therapies to prevent and treat PND.
Date Issued
2022-06-01
Date Acceptance
2022-05-23
Citation
International Journal of General Medicine, 2022, 15, pp.5349-5360
ISSN
1178-7074
Publisher
Dove Medical Press
Start Page
5349
End Page
5360
Journal / Book Title
International Journal of General Medicine
Volume
15
Copyright Statement
© 2022 Pereira et al. This work is published by Dove Medical Press Limited, and licensed under a Creative Commons Attribution License. The full terms of the License are
available at http://creativecommons.org/licenses/by/4.0/. The license permits unrestricted use, distribution, and reproduction in any medium, provided the original author
and source are credited.
available at http://creativecommons.org/licenses/by/4.0/. The license permits unrestricted use, distribution, and reproduction in any medium, provided the original author
and source are credited.
License URL
Sponsor
Wellcome Trust
Grant Number
105603/Z/14/Z
Subjects
blood-brain barrier
central nervous system
delirium
interleukins
neuroinflammation
perioperative neurocognitive disorders
1103 Clinical Sciences
Publication Status
Published