Estimation of bladder contractility from intravesical pressure-volume measurements
Author(s)
Type
Journal Article
Abstract
AimsTo describe parameters from urodynamic pressure recordings that describe urinary bladder contractility through the use of principles of muscle mechanics.MethodsSubtracted detrusor pressure and voided flow were recorded from patients undergoing filling cystometry. The isovolumetric increase of detrusor pressure, P, of a voluntary bladder contraction before voiding was used to generate a plot of (dP/dt)/P versus P. Extrapolation of the plot to the y-axis and the x-axis generated a contractility parameter, vCE (the maximum rate of pressure development) and the maximum isovolumetric pressure, P0, respectively. Similar curves were obtained in ex vivo pig bladders with different concentrations of the inotropic agent carbachol and shown in a supplement.ResultsValues of vCE, but not P0, diminished with age in female subjects. vCE was most significantly associated with the 20–80% duration of isovolumetric contraction t20–80; and a weaker association with maximum flow rate and BCI in women. P0 was not associated with any urodynamic variable in women, but in men was with t20–80 and isovolumetric pressure indices.ConclusionsThe rate of isovolumetric subtracted detrusor pressure (t20–80) increase shows a very significant association with indices of bladder contractility as derived from a derived force–velocity curve. We propose that t20–80 is a detrusor contractility parameter (DCP).
Date Issued
2017-04
Date Acceptance
2016-05-17
Citation
Neurourology and Urodynamics, 2017, 36 (4), pp.1009-1014
ISSN
0733-2467
Publisher
Wiley-Liss Inc.
Start Page
1009
End Page
1014
Journal / Book Title
Neurourology and Urodynamics
Volume
36
Issue
4
Copyright Statement
© 2016 Wiley Periodicals, Inc.
Identifier
https://onlinelibrary.wiley.com/doi/10.1002/nau.23047
Notes
17-May-2016 keywords: bladder, contractility, force–velocity relationship, urodynamics
Publication Status
Published
Date Publish Online
2016-06-06