Common variants in the chromosome 2p23 region containing the SLC30A3 (ZnT3) gene are associated with schizophrenia in female but not male individuals in a large collection of European samples
File(s)
Accepted version
Accepted version
Author(s)
Perez Becerril, C
Morris, AG
Mortimer, A
McKenna, P
de Belleroche, JS
Type
Journal Article
Abstract
Previously, we found a significant gender-specific association of schizophrenia, in a UK case/control study, with SLC30A3, a candidate that is consistently down-regulated in schizophrenia in two independent cohorts. In view of the potential significance of this finding, we extended this study to a larger cohort using GWAS data from the Psychiatric Genetic Consortium (PGC). Meta-analysis was performed for the only two SLC30A3 SNP variants (rs11126936 and rs11126929) available in most PGC cohorts. A significant association with schizophrenia was found for both variants. When meta-analysis was performed in male and female case-control subsets, an increased and gender-specific effect of allele on risk of disease was found in females for both SNPs with no significant effect in males, which was further associated with a gender-specific effect on gene expression. In conclusion, using a large European-wide sample we were able to replicate the gender-specific association previously found in a UK cohort.
Date Issued
2016-09-28
Date Acceptance
2016-09-27
Citation
Psychiatry Research, 2016, 246, pp.335-340
ISSN
1872-7123
Publisher
Elsevier
Start Page
335
End Page
340
Journal / Book Title
Psychiatry Research
Volume
246
Copyright Statement
© 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
GlaxoSmithKline Services Unlimited
Janssen Pharmaceutica NV
Grant Number
G2835
N/A
Subjects
Gender specificity
Meta-analysis of GWAS
SLC30A3
Schizophrenia
Zinc transporter 3 (ZNT3)
Medical And Health Sciences
Psychology And Cognitive Sciences
Publication Status
Published