Laser-wakefield accelerators as hard x-ray sources for 3D medical imaging of human bone
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Published version
Author(s)
Type
Journal Article
Abstract
A bright μm-sized source of hard synchrotron x-rays (critical energy Ecrit > 30 keV) based on the betatron oscillations of laser wakefield accelerated electrons has been developed. The potential of this source for medical imaging was demonstrated by performing micro-computed tomography of a human femoral trabecular bone sample, allowing full 3D reconstruction to a resolution below 50 μm. The use of a 1 cm long wakefield accelerator means that the length of the beamline (excluding the laser) is dominated by the x-ray imaging distances rather than the electron acceleration distances. The source possesses high peak brightness, which allows each image to be recorded with a single exposure and reduces the time required for a full tomographic scan. These properties make this an interesting laboratory source for many tomographic imaging applications.
Date Issued
2015-08-18
Date Acceptance
2015-07-20
Citation
Scientific Reports, 2015, 5 (7)
ISSN
2045-2322
Publisher
Nature Publishing Group: Open Access Journals - Option C
Journal / Book Title
Scientific Reports
Volume
5
Issue
7
Copyright Statement
© 2015, Rights Managed by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The
images or other third party material in this article are included in the article’s Creative Commons
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Creative Commons license, users will need to obtain permission from the license holder to reproduce
the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
images or other third party material in this article are included in the article’s Creative Commons
license, unless indicated otherwise in the credit line; if the material is not included under the
Creative Commons license, users will need to obtain permission from the license holder to reproduce
the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
License URL
Sponsor
Science and Technology Facilities Council (STFC)
The Royal Society
Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (EPSRC)
Grant Number
ST/J002062/1 John Adams Inst
UF110105
EP/H00601X/1
EP/I014462/1
Subjects
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
MICRO-COMPUTED TOMOGRAPHY
SYNCHROTRON-RADIATION
QUANTIFICATION
MINERALIZATION
BEAMS
Absorptiometry, Photon
Equipment Design
Equipment Failure Analysis
Femur
Humans
Image Enhancement
Imaging, Three-Dimensional
In Vitro Techniques
Lasers
Particle Accelerators
Reproducibility of Results
Sensitivity and Specificity
Tomography, X-Ray Computed
Femur
Humans
Tomography, X-Ray Computed
Imaging, Three-Dimensional
Image Enhancement
Absorptiometry, Photon
Sensitivity and Specificity
Reproducibility of Results
Equipment Design
Equipment Failure Analysis
Lasers
Particle Accelerators
In Vitro Techniques
Publication Status
Published
Article Number
ARTN 13244