Resistance to chemotherapy: new treatments and novel insights into an old problem
File(s)
Published version
Author(s)
Raguz, S
Yaguee, E
Type
Journal Article
Abstract
Resistance to cancer chemotherapeutic treatment is a common phenomenon, especially in progressive disease. The generation of cellular models of drug resistance has been pivotal in unravelling the main effectors of resistance to traditional chemotherapy at the molecular level (i.e. intracellular drug inactivation, detoxifying systems, defects in DNA repair, apoptosis evasion, membrane transporters and cell adhesion). The development of targeted therapies has also been followed by resistance, reminiscent of an evolutionary arms race, as exemplified by imatinib and other BCR-ABL inhibitors for the treatment of chronic myelogenous leukaemia. Although traditionally associated with the last stages of the disease, recent findings with minimally transformed pretumorigenic primary human cells indicate that the ability to generate drug resistance arises early during the tumorigenic process, before the full transformation. Novel technologies, such as genome profiling, have in certain cases predicted the outcome of chemotherapy and undoubtedly have tremendous potential for the future. In addition, the novel cancer stem cell paradigm raises the prospect of cell-targeted therapies instead of treatment directed against the whole tumour.
Date Issued
2008-07-29
Date Acceptance
2008-06-17
Citation
British Journal of Cancer, 2008, 99 (3), pp.387-391
ISSN
0007-0920
Publisher
Springer Nature [academic journals on nature.com]
Start Page
387
End Page
391
Journal / Book Title
British Journal of Cancer
Volume
99
Issue
3
Copyright Statement
© 2008 Cancer Research UK. From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000258077200002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Oncology
drug resistance
chemotherapy response
cancer stem cells
genome profiling
chronic myelogenous leukaemia
breast cancer
CHRONIC MYELOID-LEUKEMIA
HUMAN BREAST-CANCER
DRUG-RESISTANCE
GENE-EXPRESSION
STEM-CELLS
BCR-ABL
MULTIDRUG-RESISTANCE
THERAPY
AMPLIFICATION
MECHANISMS
Publication Status
Published
Date Publish Online
2008-07-29