Propagation of extrinsic fluctuations in biochemical birth–death processes
File(s)correlationsR.pdf (651.5 KB)
Accepted version
Author(s)
Bressloff, PC
Levien, E
Type
Journal Article
Abstract
Biochemical reactions are often subject to a complex fluctuating environment, which means that the corresponding reaction rates may themselves be time-varying and stochastic. If the environmental noise is common to a population of downstream processes, then the resulting rate fluctuations will induce statistical correlations between them. In this paper we investigate how such correlations depend on the form of environmental noise by considering a simple birth–death process with dynamical disorder in the birth rate. In particular, we derive expressions for the second-order statistics of two birth–death processes evolving in the same noisy environment. We find that these statistics not only depend on the second-order statistics of the environment, but the full generator of the process describing it, thus providing useful information about the environment. We illustrate our theory by considering applications to stochastic gene transcription and cell sensing.
Date Issued
2019-03
Date Acceptance
2018-11-28
Citation
Bulletin of Mathematical Biology, 2019, 81 (3), pp.800-829
ISSN
0092-8240
Publisher
Springer
Start Page
800
End Page
829
Journal / Book Title
Bulletin of Mathematical Biology
Volume
81
Issue
3
Copyright Statement
Copyright © 2018 Springer-Verlag. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11538-018-00538-0
Identifier
http://dx.doi.org/10.1007/s11538-018-00538-0
Publication Status
Published
Date Publish Online
2018-12-06