Toward Continuous Monitoring of Breath Biochemistry: A Paper-Based Wearable Sensor for Real-Time Hydrogen Peroxide Measurement in Simulated Breath
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Exhaled breath contains a large amount of biochemical and physiological information concerning one’s health and provides an alternative route to noninvasive medical diagnosis of diseases. In the case of lung diseases, hydrogen peroxide (H2O2) is an important biomarker associated with asthma, chronic obstructive pulmonary disease, and lung cancer and can be detected in exhaled breath. The current method of breath analysis involves condensation of exhaled breath, is not continuous or real time, and requires two separate and bulky devices, complicating the periodic or long-term monitoring of a patient. We report the first disposable paper-based electrochemical wearable sensor that can monitor exhaled H2O2 in artificial breath calibration-free and continuously, in real time, and can be integrated into a commercial respiratory mask for on-site testing of exhaled breath. To improve precision for sensing H2O2, we perform differential electrochemical measurement by amperometry in which screen-printed Prussian Blue-mediated and nonmediated carbon electrodes are used for differential analysis. We were able to measure H2O2 in simulated breath in a concentration-dependent manner in real time, confirming its functionality. This proposed system is versatile, and by modifying the chemistry of the sensing electrodes, our method of differential sensing can be extended to continuous monitoring of other analytes in exhaled breath.
Date Issued
2019-11-22
Date Acceptance
2019-10-15
Citation
ACS Sensors, 2019, 4 (11), pp.2945-2951
ISSN
2379-3694
Publisher
American Chemical Society
Start Page
2945
End Page
2951
Journal / Book Title
ACS Sensors
Volume
4
Issue
11
Copyright Statement
© 2019 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form inACS Sensors, after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acssensors.9b01403
Sponsor
Wellcome Trust
Engineering & Physical Science Research Council (EPSRC)
Grant Number
207687/Z/17/Z
EP/R010242/1
Subjects
electrochemical analysis
exhaled breath testing
paper-based sensors
respiratory diseases
wearables
Publication Status
Published
Date Publish Online
2019-10-15