Neuronal control of metabolism through nutrient-dependent modulation of tracheal branching
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
During adaptive angiogenesis, a key process in the etiology and treatment of cancer and obesity, the vasculature changes to meet the metabolic needs of its target tissues. Although the cues governing vascular remodeling are not fully understood, target-derived signals are generally believed to underlie this process. Here, we identify an alternative mechanism by characterizing the previously unrecognized nutrient-dependent plasticity of the Drosophila tracheal system: a network of oxygen-delivering tubules developmentally akin to mammalian blood vessels. We find that this plasticity, particularly prominent in the intestine, drives—rather than responds to—metabolic change. Mechanistically, it is regulated by distinct populations of nutrient- and oxygen-responsive neurons that, through delivery of both local and systemic insulin- and VIP-like neuropeptides, sculpt the growth of specific tracheal subsets. Thus, we describe a novel mechanism by which nutritional cues modulate neuronal activity to give rise to organ-specific, long-lasting changes in vascular architecture.
Date Issued
2014-01-16
Date Acceptance
2013-11-05
Citation
Cell, 2014, 156 (1-2), pp.69-83
ISSN
0092-8674
Publisher
Elsevier
Start Page
69
End Page
83
Journal / Book Title
Cell
Volume
156
Issue
1-2
Copyright Statement
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sponsor
Biotechnology and Biological Sciences Research Council (BBSRC)
Grant Number
BB/J007110/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Cell Biology
ENDOTHELIAL GROWTH-FACTOR
ARTERIAL DIFFERENTIATION
DROSOPHILA HOMOLOG
MIDGUT HOMEOSTASIS
TUMOR ANGIOGENESIS
REMOTE-CONTROL
CAROTID-BODY
FAT-CELLS
INSULIN
HYPOXIA
Animals
Calcium
Digestive System
Drosophila melanogaster
Humans
Models, Animal
Neovascularization, Pathologic
Neovascularization, Physiologic
Neurons
Neuropeptides
Oxygen
Signal Transduction
Vasoactive Intestinal Peptide
Digestive System
Neurons
Animals
Humans
Drosophila melanogaster
Neovascularization, Pathologic
Oxygen
Calcium
Vasoactive Intestinal Peptide
Neuropeptides
Models, Animal
Signal Transduction
Neovascularization, Physiologic
Developmental Biology
06 Biological Sciences
11 Medical and Health Sciences
Publication Status
Published
Date Publish Online
2014-01-16