Single enantiomer propeller-shaped polynuclear complexes as catalysts-proof-of-concept for enantioinduction in a Michael addition reaction
Author(s)
Type
Journal Article
Abstract
We report a family of propeller-shaped polynuclear metal complexes whose overall chirality is dictated by a single stereogenic centre within their component amino alcohol-ligand. These topologically intriguing complexes are readily prepared in enantiomerically pure form and are shown here to catalyse the conjugate addition of barbituric acids and their derivatives to nitroalkenes, with a catalyst loading of 1 mol%. Although only low levels of enantioinduction are observed, control experiments indicate that the enantioselectivity is dictated by the overall topology of the complex and not governed by binding to the tetrametallic entity, heralding a potentially new mode of catalysis.
Date Issued
2025-03-01
Date Acceptance
2025-01-29
Citation
Royal Society Open Science, 2025, 12 (3), pp.1-9
ISSN
2054-5703
Publisher
The Royal Society
Start Page
1
End Page
9
Journal / Book Title
Royal Society Open Science
Volume
12
Issue
3
Copyright Statement
Copyright © 2025 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/40151485
PII: rsos241537
Subjects
Michael addition reaction
enantioselective induction
propeller-shaped complexes
Publication Status
Published
Coverage Spatial
England
Article Number
241537
Date Publish Online
2025-03-27