Clinical predictive score for identifying metabolic dysfunction-associated steatotic liver disease in individuals with prediabetes using transient elastography
File(s)
Published version
Author(s)
Mahachai, Nutthachoke
Washirasaksiri, Chaiwat
Ariyakunaphan, Pinyapat
Kositamongkol, Chayanis
Sitasuwan, Tullaya
Type
Journal Article
Abstract
Scoring systems for metabolic dysfunction-associated steatotic liver disease (MASLD) in individuals with prediabetes have not been extensively explored. This study aimed to investigate the prevalence of MASLD and to develop predictive tools for its detection in high cardiometabolic people with prediabetes. A cross-sectional study was conducted using baseline data from the prediabetes cohort. All participants underwent transient elastography to assess liver stiffness. MASLD was defined using a controlled attenuation parameter value > 275 dB/m and/or a liver stiffness measurement ≥ 7.0 kPa. Cases with secondary causes of hepatic steatosis were excluded. Out of 400 participants, 375 were included. The observed prevalence of MASLD in individuals with prediabetes was 35.7%. The most effective predictive model included FPG ≥ 110 mg/dL; HbA1c ≥ 6.0%; sex-specific cutoffs for HDL; ALT ≥ 30 IU/L; and BMI levels. This model demonstrated good predictive performance with an AUC of 0.80 (95% CI 0.73–0.86). At a cutoff value of 4.5, the sensitivity was 70.7%, the specificity was 72.3%, the PPV was 58.8%, and the NPV was 81.5%. Our predictive model is practical, easy to use, and relies on common parameters. The scoring system should aid clinicians in determining when further investigations of MASLD are warranted among individuals with prediabetes, especially in settings with limited resources.
Date Issued
2023-12
Date Acceptance
2023-12-10
Citation
Journal of Clinical Medicine, 2023, 12 (24)
ISSN
2077-0383
Publisher
MDPI AG
Journal / Book Title
Journal of Clinical Medicine
Volume
12
Issue
24
Copyright Statement
© 2023 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://
creativecommons.org/licenses/by/
4.0/)
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://
creativecommons.org/licenses/by/
4.0/)
License URL
Identifier
https://www.mdpi.com/2077-0383/12/24/7617
Subjects
CONTROLLED ATTENUATION PARAMETER
DIAGNOSIS
FIBROSIS
General & Internal Medicine
Life Sciences & Biomedicine
Medicine, General & Internal
metabolic dysfunction-associated steatotic liver disease
NAFLD
prediabetic state
Science & Technology
screening and diagnostic method
Thais
transient elastography
Publication Status
Published
Article Number
7617
Date Publish Online
2023-12-11