Vascular permeability: flow-mediated, non-canonical notch signalling promotes barrier integrity
File(s)Braga Dispatch CB 18.pdf (299.94 KB)
Accepted version
Author(s)
Fischer, Andreas
Braga, Vania MM
Type
Journal Article
Abstract
The vascular permeability barrier must be maintained in response to changes to vessel calibre, shear stress and blood pressure. A new study reveals a remarkable mechanism for flow-mediated regulation of permeability: Notch1 activation leads to the assembly of GTPase signalling complexes at VE-cadherin contacts and a strengthening of the endothelial barrier.
Date Issued
2018-02-05
Date Acceptance
2018-02-01
Citation
Current Biology, 2018, 28 (3), pp.R119-R121
ISSN
1879-0445
Publisher
Elsevier
Start Page
R119
End Page
R121
Journal / Book Title
Current Biology
Volume
28
Issue
3
Copyright Statement
© 2018 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Biotechnology and Biological Sciences Research Council (BBSRC)
Medical Research Council (MRC)
Cancer Research UK
Medical Research Council (MRC)
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000424075300013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
BB/D019400/1
G0600791
C1282/A11980
MR/J007668/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Cell Biology
EXCHANGE FACTOR TRIO
ADHERENS JUNCTIONS
VE-CADHERIN
Publication Status
Published
Date Publish Online
2018-02-06