Size dependency of gold nanoparticles interacting with model membranes
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
The rapid development of nanotechnology has led to an increase in the number and variety of engineered nanomaterials in the environment. Gold nanoparticles (AuNPs) are an example of a commonly studied nanomaterial whose highly tailorable properties have generated significant interest through a wide range of research fields. In the present work, we characterise the AuNP-lipid membrane interaction by coupling qualitative data with quantitative measurements of the enthalpy change of interaction. We investigate the interactions between citrate-stabilised AuNPs ranging from 5 to 60 nm in diameter and large unilamellar vesicles acting as a model membrane system. Our results reveal the existence of two critical AuNP diameters which determine their fate when in contact with a lipid membrane. The results provide new insights into the size dependent interaction between AuNPs and lipid bilayers which is of direct relevance to nanotoxicology and to the design of NP vectors.
Date Issued
2020-09-17
Date Acceptance
2020-08-17
Citation
Communications Chemistry, 2020, 3, pp.1-12
ISSN
2399-3669
Publisher
Nature Research
Start Page
1
End Page
12
Journal / Book Title
Communications Chemistry
Volume
3
Copyright Statement
© The Author(s) 2020. This article is licensed under a Creative Commons
Attribution 4.0 International License, which permits use, sharing,
adaptation, distribution and reproduction in any medium or format, as long as you give
appropriate credit to the original author(s) and the source, provide a link to the Creative
Commons license, and indicate if changes were made. The images or other third party
material in this article are included in the article’s Creative Commons license, unless
indicated otherwise in a credit line to the material. If material is not included in the
article’s Creative Commons license and your intended use is not permitted by statutory
regulation or exceeds the permitted use, you will need to obtain permission directly from
the copyright holder. To view a copy of this license, visit http://creativecommons.org/
licenses/by/4.0/.
Attribution 4.0 International License, which permits use, sharing,
adaptation, distribution and reproduction in any medium or format, as long as you give
appropriate credit to the original author(s) and the source, provide a link to the Creative
Commons license, and indicate if changes were made. The images or other third party
material in this article are included in the article’s Creative Commons license, unless
indicated otherwise in a credit line to the material. If material is not included in the
article’s Creative Commons license and your intended use is not permitted by statutory
regulation or exceeds the permitted use, you will need to obtain permission directly from
the copyright holder. To view a copy of this license, visit http://creativecommons.org/
licenses/by/4.0/.
License URL
Sponsor
Commission of the European Communities
Commission of the European Communities
Engineering & Physical Science Research Council (E
Identifier
https://www.nature.com/articles/s42004-020-00377-y
Grant Number
686098
686098
CHBBC_P81995
Subjects
Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
NILE RED
ADSORPTION
LIPOSOMES
DYNAMICS
VESICLES
RELEASE
PHASE
Publication Status
Published
Article Number
130
Date Publish Online
2020-09-17