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  4. The benefit of dexamethasone in patients with COVID-19 infection is preserved in patients with diabetes.
 
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The benefit of dexamethasone in patients with COVID-19 infection is preserved in patients with diabetes.
File(s)
Diabetes Obesity Metabolism - 2022 - Eng - The benefit of dexamethasone in patients with COVID‐19 infection is preserved in.pdf (486.79 KB)
Published version
Author(s)
Eng, Pei Chia
Distaso, Walter
Durreshahwar, Hashmi
Shaikhali, Yusuf
Narendranathan, Divani
more
Type
Journal Article
Abstract
Dexamethasone significantly reduces mortality1 and is now standard treatment for patients with COVID-19 who require supplemental oxygen and/or mechanical ventilation. However, supraphysiological doses of glucocorticoids may exacerbate dysglycaemia and precipitate hyperglycaemic complications, particularly in those with or at risk of Type 2 diabetes2. The RECOVERY trial1 reported a low incidence of hyperglycaemic complications (2/1996, 0.1%), although the real-world incidence is likely to be much higher3. Type 2 diabetes itself increases the risk of severe COVID-194, and hyperglycaemia independently predicts poor outcomes5. We investigated the possibility that patients with diabetes may derive less survival benefit from steroid therapy in the setting of severe COVID-19 infection
Date Issued
2022-03-15
Date Acceptance
2022-03-12
Citation
Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics, 2022, 24 (7), pp.1385-1389
URI
http://hdl.handle.net/10044/1/96015
URL
https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.14692
DOI
https://www.dx.doi.org/10.1111/dom.14692
ISSN
1462-8902
Publisher
Wiley
Start Page
1385
End Page
1389
Journal / Book Title
Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics
Volume
24
Issue
7
Copyright Statement
© 2022 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
License URL
http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Imperial College Healthcare NHS Trust- BRC Funding
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/35293117
Grant Number
RDF01
Subjects
COVID-19
dexamethasone
diabetes
mortality
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2022-03-15
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