Treatment of obesity in young people – A systematic review and meta analysis
File(s)
Author(s)
Selvendran, Sara
Penney, NC
Aggarwal, Nikhil
Darzi, Ara
Purkayastha, Sanjay
Type
Journal Article
Abstract
Purpose: Obesity in the young is increasingly prevalent. Early, effective intervention is paramount. Treatment options are: lifestyle modifications, pharmacological therapies, endoscopic treatments and bariatric surgery. However, the relative effectiveness of these treatments in young patients remains unclear.
Material and Methods: We systematically identify and meta-analyse studies evaluating weight-loss treatments in young people (<21yrs) with obesity.
Results: From 16372 identified studies, 83 were eligible for meta-analysis. Bariatric surgery resulted in high short/medium term weight loss [pooled-estimate: 14.04kg/m2]. Lifestyle and pharmacological therapies impacted weight more moderately [pooled-estimate: 0.99kg/m2 and 0.94kg/m2 respectively].
Conclusion: Due to its high efficacy, bariatric surgery should be considered earlier when treating obesity in young people. However, due to the invasiveness and inherent risks of bariatric surgery, all other weight loss routes should be exhausted first.
Material and Methods: We systematically identify and meta-analyse studies evaluating weight-loss treatments in young people (<21yrs) with obesity.
Results: From 16372 identified studies, 83 were eligible for meta-analysis. Bariatric surgery resulted in high short/medium term weight loss [pooled-estimate: 14.04kg/m2]. Lifestyle and pharmacological therapies impacted weight more moderately [pooled-estimate: 0.99kg/m2 and 0.94kg/m2 respectively].
Conclusion: Due to its high efficacy, bariatric surgery should be considered earlier when treating obesity in young people. However, due to the invasiveness and inherent risks of bariatric surgery, all other weight loss routes should be exhausted first.
Date Issued
2018-08-01
Date Acceptance
2018-04-25
Citation
Obesity Surgery, 2018, 28 (8), pp.2537-2549
ISSN
0960-8923
Publisher
Springer Verlag
Start Page
2537
End Page
2549
Journal / Book Title
Obesity Surgery
Volume
28
Issue
8
Copyright Statement
© The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Subjects
Science & Technology
Life Sciences & Biomedicine
Surgery
Obesity
Young people
Bariatric surgery
Diet
Lifestyle
Metabolic surgery
LAPAROSCOPIC SLEEVE GASTRECTOMY
RANDOMIZED CONTROLLED-TRIAL
Y GASTRIC BYPASS
BARIATRIC SURGERY
WEIGHT-LOSS
PEDIATRIC-PATIENTS
FOLLOW-UP
OVERWEIGHT CHILDREN
ADOLESCENT OBESITY
CHILDHOOD OBESITY
1103 Clinical Sciences
1117 Public Health And Health Services
Publication Status
Published
Date Publish Online
2018-05-23