PANGEA-HIV 2: Phylogenetics and networks for generalised epidemics in Africa
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Purpose of review The HIV epidemic in sub-Saharan Africa is far from being under control and the ambitious UNAIDS targets are unlikely to be met by 2020 as declines in per-capita incidence being largely offset by demographic trends. There is an increasing number of proven and specific HIV prevention tools, but little consensus on how best to deploy them.
Recent findings Traditionally, phylogenetics has been used in HIV research to reconstruct the history of the epidemic and date zoonotic infections, whereas more recent publications focus on HIV diversity and drug resistance. However, it is also the most powerful method of source attribution available for the study of HIV transmission. The PANGEA (Phylogenetics And Networks for Generalized Epidemics in Africa) consortium has generated over 18 000 NGS HIV sequences from five countries in sub-Saharan Africa. Using phylogenetic methods, we will identify characteristics of individuals or groups, which are most likely to be at risk of infection or at risk of infecting others.
Summary Combining phylogenetics, phylodynamics and epidemiology will allow PANGEA to highlight where prevention efforts should be focussed to reduce the HIV epidemic most effectively. To maximise the public health benefit of the data, PANGEA offers accreditation to external researchers, allowing them to access the data and join the consortium. We also welcome submissions of other HIV sequences from sub-Saharan Africa to the database.
Recent findings Traditionally, phylogenetics has been used in HIV research to reconstruct the history of the epidemic and date zoonotic infections, whereas more recent publications focus on HIV diversity and drug resistance. However, it is also the most powerful method of source attribution available for the study of HIV transmission. The PANGEA (Phylogenetics And Networks for Generalized Epidemics in Africa) consortium has generated over 18 000 NGS HIV sequences from five countries in sub-Saharan Africa. Using phylogenetic methods, we will identify characteristics of individuals or groups, which are most likely to be at risk of infection or at risk of infecting others.
Summary Combining phylogenetics, phylodynamics and epidemiology will allow PANGEA to highlight where prevention efforts should be focussed to reduce the HIV epidemic most effectively. To maximise the public health benefit of the data, PANGEA offers accreditation to external researchers, allowing them to access the data and join the consortium. We also welcome submissions of other HIV sequences from sub-Saharan Africa to the database.
Date Issued
2019-05-01
Date Acceptance
2019-05-01
Citation
Current Opinion in HIV and AIDS, 2019, 14 (3), pp.173-180
ISSN
1746-630X
Publisher
Wolters Kluwer Health, Inc
Start Page
173
End Page
180
Journal / Book Title
Current Opinion in HIV and AIDS
Volume
14
Issue
3
Copyright Statement
© 2019 Wolters Kluwer Health, Inc. All rights reserved.
Sponsor
National Institutes of Health
National Institutes of Health
Medical Research Council (MRC)
National Institutes of Health
National Institutes of Health
Department for International Development (UK) (DFI
British HIV Association (BHIVA)
Bill & Melinda Gates Foundation
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000467758500004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
UM1AI068619
EPIDVH72
MR/L00528X/1
HPTN071 Substudy:Phylo PopART
PO15001410 (UMIAI068619)
N/A
A5 2017
1705CR001/LD1
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
HIV
Phylogenetics And Networks for Generalized Epidemics in Africa
phylogenetics
sub-Saharan Africa
transmission dynamics
ANTIRETROVIRAL THERAPY
FISHING COMMUNITIES
DRUG-RESISTANCE
LAKE VICTORIA
COITAL ACT
TRANSMISSION
RISK
PREVENTION
INFECTION
POPULATION
Publication Status
Published
Date Publish Online
2019-05-01