The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk
Author(s)
Type
Journal Article
Abstract
Background: The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has
been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI).
The first report showing that rs7566605 could be associated with body fatness was a genome-wide association
study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the
association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings.
BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body
fatness is related with an increased risk of breast cancer (BC).
Methods: we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194
controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk.
Results and Conclusions: In this study we were not able to find any statistically significant association between
this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast
cancer overall and by subgroups of age, or menopausal status.
been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI).
The first report showing that rs7566605 could be associated with body fatness was a genome-wide association
study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the
association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings.
BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body
fatness is related with an increased risk of breast cancer (BC).
Methods: we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194
controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk.
Results and Conclusions: In this study we were not able to find any statistically significant association between
this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast
cancer overall and by subgroups of age, or menopausal status.
Date Issued
2010-10-18
Date Acceptance
2010-10-18
Citation
BMC Cancer, 2010, 10
ISSN
1471-2407
Publisher
BioMed Central
Journal / Book Title
BMC Cancer
Volume
10
Copyright Statement
© 2010 Campa et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.
License URL
Subjects
Science & Technology
Life Sciences & Biomedicine
Oncology
ONCOLOGY
COMMON GENETIC VARIANT
POLYGENIC CONTRIBUTION
OBESITY
POPULATION
PHENOTYPES
Publication Status
Published
Article Number
563