Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
Author(s)
Type
Journal Article
Abstract
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10−8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
Date Issued
2015-12-04
Date Acceptance
2015-09-17
Citation
Nature Communications, 2015, 6
ISSN
2041-1723
Publisher
Nature Publishing Group
Journal / Book Title
Nature Communications
Volume
6
Copyright Statement
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
License URL
Sponsor
Medical Research Council (MRC)
Grant Number
MR/L01341X/1
Subjects
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
OBSTRUCTIVE PULMONARY-DISEASE
FORCED VITAL CAPACITY
WIDE ASSOCIATION
MISSING HERITABILITY
SUSCEPTIBILITY LOCUS
SEQUENCE VARIANTS
SMOKING-BEHAVIOR
GENE-EXPRESSION
METAANALYSIS
ARCHITECTURE
Adult
Aged
Aged, 80 and over
European Continental Ancestry Group
Female
Forced Expiratory Volume
Genome-Wide Association Study
Humans
Lung
Lung Diseases
Male
Middle Aged
Polymorphism, Single Nucleotide
Young Adult
UK BiLEVE
MD Multidisciplinary
Publication Status
Published
Article Number
8658