Does the vaginal microbiota plays a role in the development of cervical cancer?
File(s)
Accepted version
Author(s)
kyrgiou, M
Mitra, A
Moscicki, AB
Type
Journal Article
Abstract
Persistent infection with oncogenic human papillomavirus (HPV) is necessary but not sufficient for the development of cervical cancer. The factors promoting persistence as well those triggering carcinogenetic pathways are incompletely understood. Rapidly evolving evidence indicates that the vaginal microbiome (VM) may play a functional role (both protective and harmful) in the acquisition and persistence of HPV, and subsequent development of cervical cancer. The first studies examining the VM and the presence of an HPV infection using next-generation sequencing techniques identified higher microbial diversity in HPV-positive as opposed to HPV-negative women. Furthermore, there appears to be a temporal relationship between the VM and HPV infection in that specific community state types may be correlated with a higher chance of progression or regression of the infection. Studies describing the VM in women with preinvasive disease (squamous intraepithelial neoplasia [SIL]) consistently demonstrate a dysbiosis in women with the more severe disease. Although it is plausible that the composition of the VM may influence the host’s innate immune response, susceptibility to infection, and the development of cervical disease, the studies to date do not prove causality. Future studies should explore the causal link between the VM and the clinical outcome in longitudinal samples from existing biobanks.
Date Issued
2016-07-15
Date Acceptance
2016-07-01
Citation
Translational Research, 2016, 179, pp.168-182
ISSN
1931-5244
Publisher
Elsevier
Start Page
168
End Page
182
Journal / Book Title
Translational Research
Volume
179
Copyright Statement
© 2016 Elsevier Inc. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
British Society for Colposcopy and Cervical Pathology
Imperial College Healthcare Charity
Genesis Research Trust
Imperial College Healthcare Charity
Grant Number
N/A
7114/R17R
01020
Subjects
Science & Technology
Life Sciences & Biomedicine
Medical Laboratory Technology
Medicine, General & Internal
Medicine, Research & Experimental
General & Internal Medicine
Research & Experimental Medicine
HUMAN-PAPILLOMAVIRUS INFECTION
INNATE IMMUNE-RESPONSE
HEALTHY-YOUNG WOMEN
BACTERIAL-VAGINOSIS
INTRAEPITHELIAL NEOPLASIA
HIGH-RISK
FUSOBACTERIUM-NUCLEATUM
HORMONAL CONTRACEPTION
GARDNERELLA-VAGINALIS
NONSPECIFIC VAGINITIS
Animals
Carcinogenesis
Female
Humans
Microbiota
Neoplasm Invasiveness
Papillomaviridae
Uterine Cervical Neoplasms
Vagina
1103 Clinical Sciences
General Clinical Medicine
Publication Status
Published