Development and validation of a novel non-contact monitor of nocturnal respiration for identifying sleep-disordered breathing in patients with heart failure
File(s)Savage_et_al-2016-ESC_Heart_Failure.pdf (1.79 MB)
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Author(s)
Type
Journal Article
Abstract
Aims At least 50% of patients with heart failure (HF) may have sleep-disordered breathing (SDB). Overnight in-hospital
polysomnography (PSG) is considered the gold standard for diagnosis, but a lack of access to such testing contributes to
under-diagnosis of SDB. Therefore, there is a need for simple and reliable validated methods to aid diagnosis in patients with
HF. The aim of this study was to investigate the accuracy of a non-contact type IV screening device, SleepMinderTM (SM), compared
with in-hospital PSG for detecting SDB in patients with HF.
Methods and results The study included 75 adult patients with systolic HF and suspected SDB who underwent simultaneous
PSG and SM recordings. An algorithm was developed from the SM signals, using digital signal processing and pattern recognition
techniques to calculate the SM apnoea-hypopnoea index (AHI). This was then compared with expert-scored PSGAHI.
The SM algorithm had 70% sensitivity and 89% specificity for identifying patients with clinically significant SDB (AHI ≥ 15/h).
At this threshold, it had a positive likelihood ratio of 6.3 and a negative likelihood ratio of 0.16. The overall accuracy of the
SMAHI algorithm was 85.8% as shown by the area under a receiver operator characteristic curve. The mean AHI with SM
was 3.8/h (95% confidence interval 0.5–7.1) lower than that with PSG.
Conclusions The accuracy of the non-contact type IV screening device SM is good for clinically significant SDB in patients
with systolic HF and could be considered as a simple first step in the diagnostic pathway.
polysomnography (PSG) is considered the gold standard for diagnosis, but a lack of access to such testing contributes to
under-diagnosis of SDB. Therefore, there is a need for simple and reliable validated methods to aid diagnosis in patients with
HF. The aim of this study was to investigate the accuracy of a non-contact type IV screening device, SleepMinderTM (SM), compared
with in-hospital PSG for detecting SDB in patients with HF.
Methods and results The study included 75 adult patients with systolic HF and suspected SDB who underwent simultaneous
PSG and SM recordings. An algorithm was developed from the SM signals, using digital signal processing and pattern recognition
techniques to calculate the SM apnoea-hypopnoea index (AHI). This was then compared with expert-scored PSGAHI.
The SM algorithm had 70% sensitivity and 89% specificity for identifying patients with clinically significant SDB (AHI ≥ 15/h).
At this threshold, it had a positive likelihood ratio of 6.3 and a negative likelihood ratio of 0.16. The overall accuracy of the
SMAHI algorithm was 85.8% as shown by the area under a receiver operator characteristic curve. The mean AHI with SM
was 3.8/h (95% confidence interval 0.5–7.1) lower than that with PSG.
Conclusions The accuracy of the non-contact type IV screening device SM is good for clinically significant SDB in patients
with systolic HF and could be considered as a simple first step in the diagnostic pathway.
Date Issued
2016-09-01
Date Acceptance
2016-01-24
Citation
ESC Heart Failure, 2016, 3 (3), pp.212-219
ISSN
2055-5822
Publisher
Wiley Open Access
Start Page
212
End Page
219
Journal / Book Title
ESC Heart Failure
Volume
3
Issue
3
Copyright Statement
© 2016 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.
ESC HEART FAILURE
ESC Heart Failure 2016; 3: 212–219
Published online 1 March 2016 in Wiley Online Library (wileyonlinelibrary.com) DOI: 10.1002/ehf2.12086
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium,
provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
ESC HEART FAILURE
ESC Heart Failure 2016; 3: 212–219
Published online 1 March 2016 in Wiley Online Library (wileyonlinelibrary.com) DOI: 10.1002/ehf2.12086
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium,
provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Sponsor
ResMed Ltd
Grant Number
L02.010.062
Subjects
Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
Heart failure
Sleep-disordered breathing
Apnoea-hypopnoea index
Diagnosis
CHEYNE-STOKES RESPIRATION
ADAPTIVE SERVO-VENTILATION
APNEA SYNDROME
PREVALENCE
PRESSURE
MEN
ASSOCIATION
DIAGNOSIS
OUTCOMES
DISEASE
Publication Status
Published