Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on the risk of metachronous colorectal cancer (CRC) in patients with Lynch syndrome, analyzing data from the Prospective Lynch Syndrome Database version 5. Extended resection significantly reduced the risk of metachronous CRC in path_MLH1, path_MSH2, and path_MSH6 carriers compared to segmental resection.
Date Issued
2025-04-01
Date Acceptance
2025-02-28
Citation
British Journal of Surgery, 2025, 112 (4)
ISSN
0007-1323
Publisher
Oxford University Press (OUP)
Journal / Book Title
British Journal of Surgery
Volume
112
Issue
4
Copyright Statement
© The Author(s) 2025. Published by Oxford University Press on behalf of BJS Foundation Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
License URL
Identifier
10.1093/bjs/znaf061
Publication Status
Published
Article Number
znaf061
Date Publish Online
2025-04-15