Basin and petroleum systems modelling of the Wessex Basin, UK has been conducted to identify the maturation and migration events that charged the principal Bridport Sands and Sherwood Sandstone reservoirs at the Wytch Farm oil field. Modelling results have been compared with recent observations of magnetic enhancements at oil-water contacts (OWCs) and possibly paleocontacts (PCs) in Wytch Farm reservoirs, to assess the use of magnetic OWCs to help calibrate petroleum systems models and provide insights into the migration history of the Wessex Basin. The model predicts the Blue Lias source rock only reached maturity to the south of the Purbeck Fault, with hydrocarbon generation initiating in the Late Jurassic and peaking in the Late Cretaceous, requiring lateral migration to Wytch Farm using the Bridport Sands as the main carrier bed. Cross-fault and northward migration occurred through conduits at Creech, Bushey Farm and in offshore areas, which charged the principal structures at Wytch Farm. A ∼20 km wide Late Cretaceous juxtaposition between the Bridport Sands and Sherwood Sandstone in the hangingwall and footwall of the Purbeck Fault, respectively, led to the charging of the Sherwood Sandstone reservoir. A basin-wide Cenozoic easterly tilt of ≤1⁰ caused a westerly hydrocarbon remigration, has shifted the Bridport Sands and Sherwood Sandstone Wytch Farm structures to the west, and drastically reduced the size of Bridport Sands accumulations. There is a strong correlation between the predicted depths of Late Cretaceous and present-day OWCs with magnetic enhancements in drill cores. Multiple magnetic enhancements above the OWC at the Wareham oil field indicate the Cenozoic tilting event was periodic, forming multiple stable OWCs, with migration modelling suggesting a spill from Wytch Farm.