Nowadays, screw feeders are popular equipment in the pharmaceutical industry. However, despite the increasing research in the last decade in the manufacturing of powder-based products, there is still a lack of knowledge on the physics governing the dynamic behavior of these systems. As a result, data-driven models have often been used to address process design, optimization, and control applications. In this paper, a methodology for the modeling of twin screw feeders has been suggested. A first order plus dead time model has been developed, where a hybrid mechanistic-empirical approach has been used. Different powders and two screw feeder geometries have been investigated. The model predictions are in good agreement with the experimental measurements when the 35 mm diameter screws are employed. When the 20 mm diameter screws are used, the validity range of the model is limited for the least cohesive powders, suggesting that their screw speed-dependent resistance to flow in small screws requires further investigations.