NRP1 function and targeting in neurovascular development and eye disease
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Published version
Author(s)
Raimondi, C
Brash, JT
Fantin, A
Ruhrberg, C
Type
Journal Article
Abstract
Neuropilin 1 (NRP1) is expressed by neurons, blood vessels, immune cells and many other cell types in the mammalian body and binds a range of structurally and functionally diverse extracellular ligands to modulate organ development and function. In recent years, several types of mouse knockout models have been developed that have provided useful tools for experimental investigation of NRP1 function, and a multitude of therapeutics targeting NRP1 have been designed, mostly with the view to explore them for cancer treatment. This review provides a general overview of current knowledge of the signalling pathways that are modulated by NRP1, with particular focus on neuronal and vascular roles in the brain and retina. This review will also discuss the potential of NRP1 inhibitors for the treatment for neovascular eye diseases.
Date Issued
2016-02-27
Date Acceptance
2016-02-10
Citation
Progress in Retinal and Eye Research, 2016, 52, pp.64-83
ISSN
1350-9462
Publisher
Elsevier
Start Page
64
End Page
83
Journal / Book Title
Progress in Retinal and Eye Research
Volume
52
Copyright Statement
© 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license
(
http://creativecommons.org/licenses/by/4.0/
).
(
http://creativecommons.org/licenses/by/4.0/
).
Subjects
Ophthalmology & Optometry
1113 Ophthalmology And Optometry
Notes
publisher: Elsevier articletitle: NRP1 function and targeting in neurovascular development and eye disease journaltitle: Progress in Retinal and Eye Research articlelink: http://dx.doi.org/10.1016/j.preteyeres.2016.02.003 content_type: article copyright: © 2016 The Authors. Published by Elsevier Ltd.
Publication Status
Published
OA Location
http://www.sciencedirect.com/science/article/pii/S1350946216300064