Global epidemiology of emerging Candida auris
File(s)
Published version
Author(s)
Rhodes, Johanna
Fisher, Matthew C
Type
Journal Article
Abstract
The discovery in 2009 of a new species of yeast, Candida auris, heralded the arrival of a novel emerging human infectious disease. This review highlights the unique characteristics of C. auris that have lled to it being of public health concern worldwide, namely public health concern, namely its global emergence, its ability to cause nosocomial outbreaks in healthcare settings, its innate and emerging resistance to multiple antifungal drugs and its resilience in the face of hygiene and infection control measures. Genomic epidemiology has identified four emergences of C. auris marked by four clades of the pathogen. These clades of C. auris are genetically dissimilar and are associated with differential resistance to antifungal drugs, suggesting that they will continue to phenotypically diverge into the future. The global emergence of C. auris testifies to the unmapped nature of Kingdom Fungi, and represents a new nosocomial threat that will require enhanced infection control across diverse healthcare and community settings.
Date Issued
2019-12-01
Date Acceptance
2019-07-01
Citation
Current Opinion in Microbiology, 2019, 52, pp.84-89
ISSN
1369-5274
Publisher
Elsevier BV
Start Page
84
End Page
89
Journal / Book Title
Current Opinion in Microbiology
Volume
52
Copyright Statement
© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Sponsor
Wellcome Trust
Grant Number
105603/Z/14/Z
Subjects
0605 Microbiology
1108 Medical Microbiology
Microbiology
Publication Status
Published
Date Publish Online
2019-07-03