We introduce a new class of autoequivalences that act on the derived categories of certain vector bundles over Grassmannians. These autoequivalences arise from Grassmannian flops: they generalize Seidel-Thomas spherical twists, which can be seen as arising from standard flops. We first give a simple algebraic construction, which is well-suited to explicit computations. We then give a geometric construction using spherical functors which we prove is equivalent.