Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
Author(s)
Type
Journal Article
Abstract
Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.
Date Issued
2016-10-31
Date Acceptance
2016-09-27
Citation
Nature Genetics, 2016, 48 (12), pp.1535-1543
ISSN
1061-4036
Publisher
Nature Publishing Group
Start Page
1535
End Page
1543
Journal / Book Title
Nature Genetics
Volume
48
Issue
12
Copyright Statement
© 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Sponsor
Wellcome Trust
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000389011100014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
104803/Z/14/ZR
Subjects
Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
PAPUA-NEW-GUINEA
GENETIC DIVERSITY
RESISTANT TUBERCULOSIS
ANTIGENIC VARIATION
GENOMIC DIVERSITY
HIV-INFECTION
SOUTH-AFRICA
POPULATION
PATHOGENS
EVOLUTION
Publication Status
Published