Towards accurate and precise T 1 and extracellular volume mapping in the myocardium: a guide to current pitfalls and their solutions
File(s)
Published version
Author(s)
Cameron, D
Vassiliou, VS
Higgins, DM
Gatehouse, PD
Type
Journal Article
Abstract
Mapping of the longitudinal relaxation time (T 1) and extracellular volume (ECV) offers a means of identifying pathological changes in myocardial tissue, including diffuse changes that may be invisible to existing T 1-weighted methods. This technique has recently shown strong clinical utility for pathologies such as Anderson-Fabry disease and amyloidosis and has generated clinical interest as a possible means of detecting small changes in diffuse fibrosis; however, scatter in T 1 and ECV estimates offers challenges for detecting these changes, and bias limits comparisons between sites and vendors. There are several technical and physiological pitfalls that influence the accuracy (bias) and precision (repeatability) of T 1 and ECV mapping methods. The goal of this review is to describe the most significant of these, and detail current solutions, in order to aid scientists and clinicians to maximise the utility of T 1 mapping in their clinical or research setting. A detailed summary of technical and physiological factors, issues relating to contrast agents, and specific disease-related issues is provided, along with some considerations on the future directions of the field.
Date Issued
2017-06-12
Date Acceptance
2017-05-24
Citation
Magnetic Resonance Materials in Physics, Biology and Medicine, 2017, 31 (1), pp.143-163
ISSN
0968-5243
Publisher
Springer Verlag
Start Page
143
End Page
163
Journal / Book Title
Magnetic Resonance Materials in Physics, Biology and Medicine
Volume
31
Issue
1
Copyright Statement
© The Author(s) 2017. Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/28608328
PII: 10.1007/s10334-017-0631-2
Subjects
Accuracy
Cardiovascular magnetic resonance
Extracellular volume
Precision
T 1 mapping
Publication Status
Published
Coverage Spatial
Germany