A statistic study on raspberry vesicles: formation and properties
File(s)
Published version
Author(s)
Guo, Y
di Mare, L
Wong, JSS
Type
Journal Article
Abstract
This paper gives a statistic study on the formation of ABC raspberry vesicles under bulk swelling with DPD simulations. All vesicles formed through a disc wrap-up process, i.e. a disc micelle wraps up to form a vesicle. The lifetimes of the disc micelles before they become vesicles can be characterized as short and long (tfast and tslow). Vesicles formed with tfast have a high loading efficiency and a wide size distribution. Most of them have low membrane permeability. They resist structural deformation under shear due to their high bending rigidity. Vesicles formed with tslow have a narrow size distribution. They are small, and have low loading efficiency. A large portion of them have permeable membranes with low bending rigidity and structural defects. Shear could restructure these vesicles, and hence modify their permeability. Adjusting the repulsion between solvophobic polymers and solvents impacts on lifetimes of disc micelles. A reduction in such repulsion favours tslow. The knowledge obtained can be used to design raspberry vesicles of desired size, loading and cargo release properties.
Date Issued
2023-07-11
Date Acceptance
2023-05-22
Citation
Polymer, 2023, 280, pp.1-8
ISSN
0032-3861
Publisher
Elsevier BV
Start Page
1
End Page
8
Journal / Book Title
Polymer
Volume
280
Copyright Statement
© 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
https://www.sciencedirect.com/science/article/pii/S0032386123003889
Publication Status
Published
Article Number
126058
Date Publish Online
2023-05-24