Metabolic and process engineering for producing the peach-like aroma compound γ-decalactone in Yarrowia lipolytica
Author(s)
Type
Journal Article
Abstract
Due to its strong and unique peach-like aroma, γ-decalactone is widely used in dairy products and other foods or beverages. The oleaginous yeast Yarrowia lipolytica, which is generally regarded as safe, has shown great potential in the production of this flavor compound. Recently, the development of metabolic and process engineering has enabled the application of Y. lipolytica for the production of γ-decalactone. This Review summarizes the relevant biosynthesis and degradation pathways of Y. lipolytica, after which the related metabolic engineering strategies to increase the accumulation of γ-decalactone are summarized. In addition, the factors affecting γ-decalactone accumulation in Y. lipolytica are introduced, and corresponding process optimization strategies are discussed. Finally, the current research needs are analyzed to search for remaining challenges and future directions in this field.
Date Issued
2023-01-11
Date Acceptance
2022-12-13
Citation
Journal of Agricultural and Food Chemistry, 2023, 71 (1), pp.110-120
ISSN
0021-8561
Publisher
American Chemical Society
Start Page
110
End Page
120
Journal / Book Title
Journal of Agricultural and Food Chemistry
Volume
71
Issue
1
Copyright Statement
Copyright © 2022 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Agricultural and Food Chemistry, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jafc.2c07356
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/36579964
Subjects
?-decalactone
?-oxidation
ACYL-COA OXIDASE
Agriculture
Agriculture, Multidisciplinary
BIOSYNTHESIS
BIOTECHNOLOGICAL PRODUCTION
CASTOR-OIL
Chemistry
Chemistry, Applied
FATTY-ACID
flavor
Food Science & Technology
LACTONE PRODUCTION
Life Sciences & Biomedicine
metabolic engineering
METHYL RICINOLEATE
PEROXISOMAL BETA-OXIDATION
Physical Sciences
process engineering
RICINOLEIC ACID
Science & Technology
Yarrowia lipolytica
YEAST
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2022-12-29