Group-wise Parcellation of the Cortex through Multi-scale Spectral Clustering
File(s)Neuroimage_SCV4.pdf (11.81 MB)
Accepted version
Author(s)
Parsiot, S
Arslan, S
Passerat-Palmbach, J
Wells, WM
Rueckert, D
Type
Journal Article
Abstract
The delineation of functionally and structurally distinct regions as well as their connectivity can provide key knowledge towards understanding the brain's behaviour and function. Cytoarchitecture has long been the gold standard for such parcellation tasks, but has poor scalability and cannot be mapped in vivo. Functional and diffusion magnetic resonance imaging allow in vivo mapping of brain's connectivity and the parcellation of the brain based on local connectivity information. Several methods have been developed for single subject connectivity driven parcellation, but very few have tackled the task of group-wise parcellation, which is essential for uncovering group specific behaviours. In this paper, we propose a group-wise connectivity-driven parcellation method based on spectral clustering that captures local connectivity information at multiple scales and directly enforces correspondences between subjects. The method is applied to diffusion Magnetic Resonance Imaging driven parcellation on two independent groups of 50 subjects from the Human Connectome Project. Promising quantitative and qualitative results in terms of information loss, modality comparisons, group consistency and inter-group similarities demonstrate the potential of the method.
Date Issued
2016-05-15
Date Acceptance
2016-05-10
Citation
Neuroimage, 2016, 136, pp.68-83
ISSN
1095-9572
Publisher
Elsevier
Start Page
68
End Page
83
Journal / Book Title
Neuroimage
Volume
136
Copyright Statement
© 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Commission of the European Communities
Grant Number
319456
Subjects
Connectomics
Cortex parcellation
Diffusion Magnetic Resonance Imaging
Group-wise analysis
Spectral clustering
Neurology & Neurosurgery
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Publication Status
Published