Automation of cleaning and reconstructing residential address histories to assign environmental exposures in longitudinal studies
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Background: We have developed an open-source ALgorithm for Generating Address Exposures (ALGAE) that cleans residential address records to construct address histories and assign spatially-determined exposuresto cohort participants. The first application of this algorithm was to construct prenatal and early-life air pollution exposure for individuals of the Avon Longitudinal Study of Parents and Children (ALSPAC)in the South West of Englandusingpreviously estimated particulate matter ≤10 μm (PM10) concentrations. Methods: ALSPAC recruited 14,541 pregnant women between 1991and 1992. We assignedtrimester-specific estimated PM10exposures for 12,752 pregnancies,and first year of life exposures for 12,525births, based on maternal residence and residential mobility. Results: Average PM10exposure was32.6 μg/m3(StDev. 3.0 μg/m3) during pregnancy and 31.4 μg/m3(StDev. 2.6 μg/m3) during the first year of life. 6.7% ofwomen changedaddress during pregnancy, and 18.0% moved during first year of lifeof their infant. Exposure differences ranged from -5.3 μg/m3 to 12.4 μg/m3(up to 26% difference) during pregnancy and -7.22 μg/m3to 7.64 μg/m3(up to 27% difference) in the first year of life,when comparing estimated exposure using the address at birth and that assessedusing the complete cleaned address history. For the majority of individualsexposure changed by <5% but some relatively large changes were seen both in pregnancy and infancy.Conclusion: ALGAE provides a generic andadaptable, open-source solution to clean addresses stored in acohort contact database and assign life-stage specific exposureestimates with the potential to reduce exposure misclassification.
Date Issued
2020-04-15
Date Acceptance
2019-08-09
Citation
International Journal of Epidemiology, 2020, 49 (Supplement_1), pp.i49-i56
ISSN
1464-3685
Publisher
Oxford University Press (OUP)
Start Page
i49
End Page
i56
Journal / Book Title
International Journal of Epidemiology
Volume
49
Issue
Supplement_1
Copyright Statement
© The Author(s) 2020. Published by Oxford University Press on behalf of the International Epidemiological Association.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Sponsor
Public Health England
Medical Research Council (MRC)
Identifier
https://academic.oup.com/ije/article/49/Supplement_1/i49/5819943
Grant Number
6509268
MR/L01341X/1
Subjects
Residential mobility
air pollution
cohort studies
exposure measurement error
pregnancy
reproductive health
0104 Statistics
1117 Public Health and Health Services
Epidemiology
Publication Status
Published
Date Publish Online
2020-04-15