Evaluating insecticide resistance across African districts to aid malaria control decisions
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Published version
Author(s)
Type
Journal Article
Abstract
Malaria vector control may be compromised by resistance to insecticides in vector populations. Actions to mitigate against resistance rely on surveillance using standard susceptibility tests, but there are large gaps in the monitoring data across Africa. Using a published geostatistical ensemble model, we have generated maps that bridge these gaps and consider the likelihood that resistance exceeds recommended thresholds. Our results show that this model provides more accurate next-year predictions than two simpler approaches. We have used the model to generate district-level maps for the probability that pyrethroid resistance in Anopheles gambiae s.l. exceeds the World Health Organization thresholds for susceptibility and confirmed resistance. In addition, we have mapped the three criteria for the deployment of piperonyl butoxide-treated nets that mitigate against the effects of metabolic resistance to pyrethroids. This includes a critical review of the evidence for presence of cytochrome P450-mediated metabolic resistance mechanisms across Africa. The maps for pyrethroid resistance are available on the IR Mapper website, where they can be viewed alongside the latest survey data.
Date Issued
2020-09-08
Date Acceptance
2020-07-01
Citation
Proceedings of the National Academy of Sciences, 2020, 117 (36), pp.22042-22050
ISSN
0027-8424
Publisher
Proceedings of the National Academy of Sciences
Start Page
22042
End Page
22050
Journal / Book Title
Proceedings of the National Academy of Sciences
Volume
117
Issue
36
Copyright Statement
This open access article is distributed under Creative Commons Attribution-NonCommercial NoDerivatives License 4.0 (CC BY-NC-ND).
Identifier
http://dx.doi.org/10.1073/pnas.2006781117
Publication Status
Published
Date Publish Online
2020-08-25