Non-invasive amelioration of essential tremor via phase-locked disruption of its temporal coherence
File(s)
Published version
Supporting information
Author(s)
Type
Journal Article
Abstract
Abstract Aberrant neural oscillations hallmark numerous brain disorders. Here, we first report a method to track the phase of neural oscillations in real-time via endpoint-corrected Hilbert transform (ecHT) that mitigates the characteristic Gibbs distortion. We then used ecHT to show that the aberrant neural oscillation that hallmarks essential tremor (ET) syndrome, the most common adult movement disorder, can be noninvasively suppressed via electrical stimulation of the cerebellum phase-locked to the tremor. The tremor suppression is sustained after the end of the stimulation and can be phenomenologically predicted. Finally, using feature-based statistical-learning and neurophysiological-modelling we show that the suppression of ET is mechanistically attributed to a disruption of the temporal coherence of the oscillation via perturbation of the tremor generating a cascade of synchronous activity in the olivocerebellar loop. The suppression of aberrant neural oscillation via phase-locked driven disruption of temporal coherence may represent a powerful neuromodulatory strategy to treat brain disorders.
Date Issued
2020-06-24
Date Acceptance
2020-12-04
Citation
Nature Communications, 2020, 12
ISSN
2041-1723
Publisher
Cold Spring Harbor Laboratory
Journal / Book Title
Nature Communications
Volume
12
Copyright Statement
© The Author(s) 2021. This article is licensed under a Creative CommonsAttribution 4.0 International License, which permits use, sharing,adaptation, distribution and reproduction in any medium or format, as long as you giveappropriate credit to the original author(s) and the source, provide a link to the CreativeCommons license, and indicate if changes were made. The images or other third partymaterial in this article are included in the article’s Creative Commons license, unlessindicated otherwise in a credit line to the material. If material is not included in thearticle’s Creative Commons license and your intended use is not permitted by statutoryregulation or exceeds the permitted use, you will need to obtain permission directly fromthe copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
License URL
Sponsor
UK DRI Ltd
Wellcome Trust
Engineering & Physical Science Research Council (EPSRC)
Grant Number
4050641385
097443/B/11/Z
EP/N014529/1
Subjects
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
DEEP BRAIN-STIMULATION
PARKINSONS-DISEASE
FIRING RATES
CEREBELLUM
ACTIVATION
NETWORK
Adult
Aged
Aged, 80 and over
Algorithms
Brain
Cerebellum
Deep Brain Stimulation
Essential Tremor
Female
Humans
Male
Middle Aged
Models, Neurological
Neurophysiological Monitoring
Transcranial Direct Current Stimulation
Brain
Cerebellum
Humans
Essential Tremor
Deep Brain Stimulation
Algorithms
Models, Neurological
Adult
Aged
Aged, 80 and over
Middle Aged
Female
Male
Neurophysiological Monitoring
Transcranial Direct Current Stimulation
Publication Status
Published
Article Number
ARTN 363