Effects of canagliflozin on heart failure outcomes associated with preserved and reduced ejection fraction in type 2 diabetes: results from the CANVAS Program
File(s)HFrEF vs HFpEF_research letter_190112gf.pdf (635.22 KB)
Accepted version
Author(s)
Type
Journal Article
Abstract
Patients with type 2 diabetes mellitus are at high risk of developing heart failure (HF).1 Sodium glucose co-transporter 2 (SGLT2) inhibitors have been demonstrated, in large scale trials, to reduce the risk of HF events in patients with type 2 diabetes deemed to be at high risk based on established cardiovascular disease or multiple risk factors.2-4 However, it is unclear whether benefits are experienced across the broad spectrum of HF patients that includes those with preserved (HFpEF) as well as reduced ejection fraction (HFrEF).
Date Issued
2019-05-28
Date Acceptance
2019-02-22
Citation
Circulation, 2019, 139 (22), pp.2591-2593
ISSN
0009-7322
Publisher
American Heart Association
Start Page
2591
End Page
2593
Journal / Book Title
Circulation
Volume
139
Issue
22
Copyright Statement
© 2019 American Heart Association, Inc.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/30882240
Subjects
Canagliflozin
SGLT2 inhibitor
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2019-03-17