Repurposing existing drugs for the treatment of COVID-19
File(s)
Author(s)
Type
Journal Article
Abstract
The rapid global spread and significant mortality associated with the coronavirus disease (COVID-19) caused by SARS-CoV-2 viral infection has spurred an urgent race to find effective treatments. Repurposing existing drugs is a particularly attractive approach as pharmacokinetic and safety data already exist, thus development can leapfrog straight to clinical trials of efficacy, generating results far more quickly than de novo drug development. This review summarizes the state of play for the principle drugs identified as candidates to be repurposed for treating COVID-19 grouped by broad mechanism of action: antiviral, immune enhancing, and anti-inflammatory or immunomodulatory. Patient selection, particularly with regard to disease stage, is likely to be key. To date only dexamethasone and remedesivir have been shown to be effective, but several other promising candidates are in trials.
Date Issued
2020-10-01
Date Acceptance
2020-07-21
Citation
Annals of the American Thoracic Society, 2020, 17 (10), pp.1186-1194
ISSN
1546-3222
Publisher
American Thoracic Society
Start Page
1186
End Page
1194
Journal / Book Title
Annals of the American Thoracic Society
Volume
17
Issue
10
Copyright Statement
©2020 by the American Thoracic Society. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/). For commercial usage and reprints, please contact Diane Gern (dgern@thoracic.org).
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/32692580
Subjects
Science & Technology
Life Sciences & Biomedicine
Respiratory System
coronavirus
COVID-19
severe acute respiratory syndrome coronavirus 2
therapeutics
ACUTE RESPIRATORY SYNDROME
OFF-LABEL USE
ANTIMALARIAL-DRUGS
CYTOKINE STORM
I INTERFERON
IFN-BETA
SARS
CHLOROQUINE
INFECTIONS
PNEUMONIA
COVID-19
coronavirus
severe acute respiratory syndrome coronavirus 2
therapeutics
Anti-Inflammatory Agents
Antiviral Agents
Betacoronavirus
COVID-19
Coronavirus Infections
Drug Discovery
Drug Repositioning
Humans
Immunologic Factors
Pandemics
Patient Selection
Pneumonia, Viral
SARS-CoV-2
Humans
Pneumonia, Viral
Coronavirus Infections
Anti-Inflammatory Agents
Immunologic Factors
Antiviral Agents
Patient Selection
Drug Discovery
Drug Repositioning
Pandemics
Betacoronavirus
COVID-19
SARS-CoV-2
Respiratory System
1103 Clinical Sciences
Publication Status
Published
Coverage Spatial
United States