Multiplexed immunosensors for point-of-care diagnostic applications
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Accurate, reliable, and cost-effective immunosensors are clinically important for the early diagnosis and monitoring of progressive diseases, and multiplexed sensing is a promising strategy for the next generation of diagnostics. This strategy allows for the simultaneous detection and quantification of multiple biomarkers with significantly enhanced reproducibility and reliability, whilst requiring smaller sample volumes, fewer materials, and shorter average analysis time for individual biomarkers than individual tests. In this opinionated review, we compare different techniques for the development of multiplexed immunosensors. We review the state-of-the-art approaches in the field of multiplexed immunosensors using electrical, electrochemical, and optical methods. The barriers that prevent translating this sensing strategy into clinics are outlined together with the potential solutions. We also share our vision on how multiplexed immunosensors will continue their evolution in the coming years.
Date Issued
2022-05-01
Date Acceptance
2022-01-25
Citation
Biosensors and Bioelectronics, 2022, 203
ISSN
0956-5663
Publisher
Elsevier
Journal / Book Title
Biosensors and Bioelectronics
Volume
203
Copyright Statement
© 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
License URL
Sponsor
UK DRI Ltd
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/35134685
PII: S0956-5663(22)00090-2
Grant Number
DRI-CORE2020-CRT
Subjects
Multiplexed immunosensors
Point-of-care detection
Progressive disease
Protein biomarkers
Publication Status
Published
Coverage Spatial
England
Article Number
ARTN 114050
Date Publish Online
2022-01-29